Report for Ergonomic-Free-Samples for Students-Myassignmenthelp

Question: Compose a Report for Ergonomic Solutions for Arthritic Workers. Answer: Presentation: The report is set up to be introduced to the governing body of Amazing Suppliers that has been presenting change in work move of their distribution center staffs. Stunning Suppliers is an enormous association that provisions wide scope of merchandise that they sell it through online channel. Since the interest of items sold is very high, it has been concluded that in certain territories. Twenty hour of working would be presented and this move framework would be significantly affecting distribution center staffs. Report plans to dissect the effect of expanded, additional time and long working hours and difficulties looked by association. Twenty four working hours for the distribution center staffs would unfavorably influencing the wellbeing and prosperity of representatives. Long working hours are possibly risky to wellbeing of laborers. Long working hours accompanies the test and danger of word related disease and wounds. Difficulties can be confronted identifying with work life pari ty and laborers may confront mental issues because of since quite a while ago broadened working hours. They would confront changes dozing and eating stage. Another issue is looked as far as wastefulness in the exhibition of laborers because of disturbance of circadian cadence joined with exhaustion and rest deficiency. Association would have lower proficiency of execution for stockroom staffs. Long working movement would case long haul impacts concerning wellbeing and higher social and monetary expense for both association and society overall (Broberg and Hall-Andersen 2014). On other hand, twelve hour working movement can be tiring for managerial staffs. In any case, it doesn't accompanies a few difficulties as it consolidates an even remaining tasks at hand and successive rest delays. Discoveries: From the above conversation, it is found out that all-inclusive working hours accompanies a few medical problems looked by representatives. Exhaustion is one of the regular grumble among the laborers who are working for anomalous hours. It is perceptible after the night move of laborers and least on the evening shift. This specific issue looked by laborers is to some degree hard to gauge Secondly, it will bring down proficient execution of workers because of long haul sway on wellbeing. In this specific segment, the utilization of idea of ergonomics is talked about corresponding to difficulties looked because of move in working hours. Another issue that is looked by laborers is that twenty hour working movement has an important mediate with family and public activity. This would bring about psychosomatic issue and mental pressure. Extraordinary challenges would be looked by distribution center staff of association in brushing working and social occasions (Haslam and Waterson 2013). A ccording to multifaceted nature of individual obligations, family time, coordination of laborers with family time table will get troublesome. Ergonomics or factor of human application have been found out to decidedly influence the presentation of laborers, fulfillment and wellbeing and security of laborers. This would affect the general execution of association in both immediate and circuitous way. Ergonomics is a logical methodology that is identified with the comprehension of connection among human and different components of a framework. Association rehearsing ergonomics adds to assessment and planning of undertakings employments, condition, framework and items so it is good with the capacities, needs and restriction of individuals. Execution of models of ergonomics would help in limiting the unfavorable effect of progress in moving calendars and prompting better spot for working (Hignett et al. 2013). The timetable of moving is required to be structured as per ergonomic measures. From the conversation of this specific segment, it is induced that association experiences issues in estimating issues, for example, weakness. Weakness that are caused to laborers because of long hour of works can be measures utilizing a few strategies or devices of examination, for example, Cognitive testing, multi dormancy test and Epworth Sleepiness scale. It would help in limiting the unfriendly effects of move plan by restricting the effects, decreasing the pressure, keeping away from back to back number of delayed night shifts, limiting amassing of rest deficiencies, circadian disturbance and weakness. Overabundance of back to back working days and delayed working hours are associated with expanded danger of ergonomics related wounds. Ergonomics issues is related with lack of sleep and lost workdays because of this nonstop work move. Lack of sleep may prompt harm as far as tendon, muscle and ligament injury. This prompts expanded danger of ergonomic wounds. It has been found fr om past research that twelve hour working movement isn't viewed as characteristically harming wellbeing and representatives and they are not viewed as perilous for workers wellbeing. Overabundance working hours is carried wounds because of inadmissible relaxation time (Franssila et al. 2016). A portion of the rules as indicated by ergonomics for planning the moving framework are as per the following: Gradually turning framework isn't viewed as better contrasted with rapidly pivoting moving framework as they help with limiting the aggregate rest deficiency degree and have less obstruction with circadian rhythms (Young et al. 2015). Lasting night move of twenty four hour move is allowed uniquely for distribution center staffs and they ought to be ensured with most significant level of wellbeing by making total acclimation to night work plan. Master ached working shift should be thought about when there is reasonableness in the remaining burden and laborers ought to be furnish with adequate rest. Move framework is structured so that helps in limiting the presentation to poisonous substances and weariness gathering. So as to meet inclinations and requirements of laborers, association should advance adaptable working course of action. For decrease of truncation of rest, association ought to maintain a strategic distance from ambitious start of morning shift and thus the decrease of danger of blunders and weakness. The moving framework soul be standard and free end of the week ought to be ensured and this would help distribution center staffs in advantageously making the most of their relaxation and social time. There ought to be clockwise pivot as it is corresponding to endogenous circadian mood and it helps in evading snappy changeovers and prompting quick recuperation by permitting longer rest periods. The equalization in work life for representatives working in association is putting expanded significance in ergonomics. This idea think about representing the two assorted varieties among people and gathering of laborers. There are numerous compelling rules for ingraining practice of ergonomics inside the workplace. Improvement in usage of ergonomics will help in diminishing the hazard identified with injury of occupation. Practice of ergonomics furnish with positive advantages, for example, improved wellbeing and keeping laborers solid (Martin et al. 2013). Presently, examining the ideas of ergonomics corresponding to bring down laborer effectiveness. It is done as far as expanded efficiency coming about because of expanding adequacy of laborers or distribution center and managerial staffs. Laborers can achieve their assignments effectively when they have more vitality and feel more grounded in the earth where they are working. Positive ergonomic strategies is utilized by association is foundation of decides that helps in encouraging strength of workers (Yang et al. 2015). Dangers of representative wounds and medical problems can be decreased by Amazing Suppliers by clinging to the standards of ergonomics. Profitability among stockroom and managerial staffs of association will be improved by choosing best ergonomic arrangement. Workstation will be made increasingly effective by structuring work in great stance and better statures and ranges. Solace level of workers is extensively affected by the workplace ergonomics. Use of this idea he lps in planning work so that work is more secure and proficient (Falzon 2014). Laborers and staffs of Amazing Suppliers would have expanded efficiency and would feel the solace in performing employments by actualizing arrangement of ergonomics. Estimating of different medical problems looked by representatives because of long working hours: Epworth drowsiness scale-It is a self-rating scale on eight things and aides in surveying the probability of representatives of falling rest. The probability of nodding off is appraised on scale running from 0 to 3. 3 demonstrates high possibility of nodding off and 0 shows no possibility of nodding off. More noteworthy rest penchant is reflected by higher scores and complete score ranges from 0 to 24. Workers grumbling over the top day time languor would score 12 or higher. Along these lines, Amazing Suppliers can the measure the exhaustion of workers (Walker et al. 2017). Multi idleness test-Multi dormancy test is an instrument of diagnosing rest issue. This specific device is utilized in estimating rest inactivity that is time slipped by from the beginning of snooze during day time to the primary indication of rest. The possibility that shapes the premise of rest is that individuals will snoozing quicker when they are feeling tired. This test is utilized for making qualification between unnecessary day time drowsiness and physical sluggishness. This test is applied in workplace for evaluating the availability of individual to nod off in a helpful setting. Multi idleness test helps in estimating the exhaustion level of representatives (Hanson 2013). Intellectual testing strategies Cognitive testing is a mental testing that helps in assessment of useful limit of an individual workers. This specific testing depends on estimating execution of assignments for surveying subjective working and this prompts seriousness of intellectual debilitation foundation. It is the essential path for building up seriousness of subjective debilitation (Dekker et al. 2013). Work of the considerable number of proportions of testing would help association in assessing the effect of the moving hours on prosperity and per

Genetic Engineering Essay -- Genetics Science Food Agriculture Essays

Hereditary Engineering When we imagine our future, we for the most part envision a future liberated from malady and physical ailment, however have you at any point thought about how a sickness free society will be cultivated? In the twenty-first century our reality will be an altogether different spot as a result of hereditary control and designing. There are numerous upsides and downsides to this discussion, yet it is irrefutable that the impacts from the new disclosures in the field of hereditary qualities are expansive and profound affecting. Hereditary designing is a radical new innovation, one that separates essential boundaries, between species, yet additionally between people, creatures, and plants. By joining the qualities of divergent and inconsequential species, forever modifying their hereditary codes, novel living beings are made that will pass the hereditary changes onto their posterity through heredity. Researchers are presently cutting, embeddings, recombining, improving, altering, and progr amming hereditary material. Creature qualities and even human qualities are being embedded into plants or creatures making unheard of transgenic living things. Without precedent for history, individuals are turning into the planners of life. Bio-specialists will make a huge number of novel life forms throughout the following barely any years. The possibility is alarming. First we should see that hereditary designing offers numerous potential advantages to the twenty-first century in the two fields of agribusiness and medication. In farming, we would now be able to develop plants and animals quicker, more grounded, and simpler. We can change plants to have them grow multiple times bigger than their unique size, and we can make creatures without guardians by cloning (Scott). In medication, hereditary designing has upset the field into something totally new. We currently produce fixes that are explicitly custom fitted to sicknesses, which have extended the normal life expectancy by right around ten years, recognize and dispense with birth absconds in babies, and have individuals that are more beneficial now than whenever ever (Epstein). In any case, with that practically boundless force, there is a significant expense for the twenty-first century to pay. With every reward we as a general public get from hereditary qualities, we additionally made hereditarily changed super-ailments. Qualities from microbes, infections, and creepy crawlies, which have never been a piece of the human eating routine, are being grafted into our food. Hereditary building isn't a precise science. Researchers can... .... They need to charge for items, and a high piece of the overall industry. I feel there are major defects with the hereditary building approach, and am exceptionally suspicious of the individuals who might be driving its bearing. I insist our privileges as people and as a network to settle on a decision about the bearing we take, for on the off chance that we don't have that, at that point why endured all the muddled parts of having choice? In this way, as we approach the twenty-first century, we go into the domain of the obscure. Be that as it may, it is certainly a future that will be honored and reviled with hereditary building, and one that will glance back at the nineteenth century and recollect the improvement that affected it the most as hereditary designing. Book reference: Works Cited Epstein, Dr. Ron. Why You Should Be Concerned About Genetically Engineered Food. 2 Nov. 1999. Hawaleshka, Danylo. Unnatural Selection. Maclean's 20 Jan. 1997. 20 Oct. 1999. Wellbeing, Environmental, and Ethical Concerns of Genetically Engineered Foods. 11 July 1999. 26 Oct. 1999. Scott, Mary. Food Focus: Genetically Engineered Foods - Answers to Frequently Asked Questions. Natural Foods Merchandises Nov.1997. 26 Oct. 1999 .

Everything You Need to Know About Big Data as a Service (BDaaS)

Everything You Need to Know About Big Data as a Service (BDaaS) Over the past few years, traditional business and market management have changed dramatically in reference to traditional ways. New approaches towards customer acquisition, activation, and retention have put information on behavioral patterns and insights that can be derived from data influx in the front rows. By proper analysis of these properties, entrepreneurs can achieve productivity. By lack of it, enterprises are destined for burial under the increasing amount of competition.Accessibility of technology and its overwhelming usage in everyday life influenced the massive increase in data amounts that are available to entrepreneurs. However, the practical usage of the data is dependent on the ability to store, manage and analyze it adequately. Before the Big Data as a Service technology appeared as an influential opportunity for small businesses and organizations, these domains were reserved only for those who could afford them â€" i.e. big corporations. Big Data as a Service or BD aaS enables new competitive advantages as well as profitable management of customers and the market in order to ensure business growth and is highly accessible due to reduced costs of data processing endeavors. © Shutterstock.com | bleakstarIn this article we will present important information, constituents and processes of BDaaS as well as challenges which it faces through sections 1) Big Data as a Service â€" Defining the Term; 2) Types of BDaaS; 3) BDaaS Framework, 4) Requirements for BDaaS; 5) Advantages and Disadvantages of BDaaS and 6) Differences of BDaaS in Relation to Traditional Environment and Big Data.BIG DATA AS A SERVICE â€" DEFINING THE TERMBig Data as a Service is an emerging technology-focused on efficient and ubiquitous availability of constructive data processing. It is a cloud-based spectrum of hardware and software services for storage and analysis of increased amounts of diverse information which have emerged in the past few years due to technological advances and intrinsic presence of technology usage in everyday life (social networks, online media, etc.). The goal of BDaaS technology is to provide cost-efficient and valuable insights for organizations and small busi nesses in order to increase their competitiveness, innovation and, consequently, revenues.Ingredients of BDaaS High Functioning Service-Oriented Architecture: BDaaS technology provides a highly functional architecture which includes big data storage infrastructure, data processing modules and diverse analytical tools whose purpose is to reduce customer’s expenditures on employment of programming experts and data scientists as well as opportunities for targeted usage of these diverse layers according to specific needs. Moreover, the Service-Oriented Architecture (SOA) of BDaaS leverages each of the above-mentioned services individually as well as connects them into a whole â€" which allows a comprehensive approach to specific business requirements. Cloud Virtualization Capabilities: The above-mentioned structures of BDaaS are based on cloud-computing and horizontal scalability. Essentially, this means that data is stored and processed on multiple processers that have specified task s regarding the result required. The horizontal scalability enables these separate entities to work as a single logical unit and allows introducing new ones if the amount of data increases. On the other side, systems such as Hadoop are open-source storage technologies that operate on vertical scalability basis. This means they upgrade properties of single processors in order to manage increased amounts of data (and are thus dependent on technology advances). Complex Event-Driven Processing: BDaaS technology enables data management in three modules â€" explanatory, descriptive and predictive. Through different sorting and analytical approaches, customers can obtain valuable information regarding issues, threats, opportunities and possibilities that can be used for overall business growth. Moreover, due to real-time processing techniques and on-demand features, the BDaaS system is not only timely and accurate but also less costly. Business Intelligence Tools: Big Data as a Service use s application software for reporting, querying, online analytical processing, data mining, and numerous other elements in order to transform raw (and frequently unstructured) data into constructive information for business intelligence â€" that is, into information that can increase actual business efficiency.Key elements of Big Data Which BDaaS AddressesVelocity. Velocity of Big Data represents the speed of data fluctuation through systems. It is an important dimension of Big Data management as it leverages computing abilities in order to generate information with regard to real-time events. This is done through complex event processing applications. The ‘streaming data’ requires sufficient storage capabilities which are ensured by BDaaS’s horizontal scalability, as well as optimized response intervals â€" through new technologies such as NoSQL which retrieve data in lesser amounts of time.Volume. The size of Big Data datasets can amount to multiple petabytes and thus requir es adequate distributed computing and horizontal scalability features. The volume of data is obtained and managed through implementation of thousands of nodes (individual processing units) with paralleled but particular tasks. The accuracy of predictive and descriptive analysis rises proportionally with increased number of processing units.Variety. Big Data as a Service technologies expanded processing abilities from only structured data to unstructured data as well. The applications used by BDaaS effectively extract valuable data for usage from the majority of raw data which fluctuates through the systems. The proper managing of the variety dimension of Big Data results in increased ROI figures regarding the technology infrastructure.Statistics on BDaaSWhen looking at figures we must combine individual statistics on key building blocks of BDaaS â€" cloud computing and Big Data. Statistics derived from tendencies of these two constituents imply a continuous growth of BDaaS usage as well as its firm incorporation into the IT market.The total amount of data influx achieved over the past fifty years equals to data influx amount that is achieved in two day nowadays15% of all IT investment is focused on cloud-based systems (with the estimated rise to 35% by 2021)50% of data in organizations will be stored on cloud-based systems by 2016Big Data market is predicted to reach 17 billion dollars revenue over the course of 2015 (with the estimated rise to 88 billion dollars by 2021)Big Data as a Service market is estimated to a 2.55 billion dollar worth according to the above stated predictions (with the estimated rise to around 30 billion dollars by 2021)Industries with increased Big Data and cloud computing usage are business, finance, media, retail and telecommunications.Almost 50% of data in organizations is predicted to be stored on cloud-based systems by 2016.The total amount of data influx achieved over the past fifty years equals to data influx amount which is ac hieved in two day nowadays.TYPES LAYERS OF BDAASBDaaS technology implements Infrastructure as a Service (IaaS), Platform as a Service (PaaS) and Software as a Service (SaaS) tools and techniques in order to provide complete storage and analysis data processing. Moreover, BDaaS implements Hadoop infrastructures but can upgrade their efficiency through the incorporation of different software according to needs of particular data processing. With reference to these layers, we can divide BDaaS into four types. BDaaS typesLayersIaaS. In the IaaS layer users are offered generic infrastructures for data storage in cloud environment as well as on-demand employment of nodes for data processing. The IaaS layer provides most opportunities for direct influence on the BDaaS technology (scalability, computing, and accessibility of raw data) but requires proficient programming and data skills. Amazon’s EC2 storage platform is excellent software for IaaS properties.PaaS. Platform as a service incorporates basic infrastructure with provisionary features regarding application deployment. It requires expertise in programming and data science is necessary to maintain the layer. However, it does reduce the involvement of customers in matters of hardware and storage as it is mainly based in virtual surroundings. Some examples of PaaS layer are Heroku, Google App Engine, and Force.com.SaaS. SaaS layer enables users to access applications without spending time and finances on programming, installation and m aintenance of the underlying software. The service provider deals with these features while the customer uses applications on demand. However, customers cannot access infrastructure layers and raw data from the SaaS layer.TypesCore BDaaS. Core BDaaS is considerably generic and uses infrastructures such as Hadoop, Google’s Map Reduce, Spark or individually written Java-scripts. Many users opt for Hadoop-based infrastructures because it is free open source software. Core BDaaS combines this basic infrastructure with storage applications such as Amazon’s S3 or Hive and NoSQL processing engines such as YARN. A comprehensive Core BDaaS technology is Amazon’s Elastic MapReduce (EMR).Performance BDaaS. Performance BDaaS uses basic infrastructure but includes provisionary usage of other software and hardware (for example, Altiscale) services in order to optimize performance for specific purposes â€" increasing scalability and computing potential at predictable costs.Feature BDaaS. Fea ture BDaaS evolved in order to provide possibilities of application definition according to needs of particular assignments. Essentially, this means that the basic infrastructure allows employment of different basic software regarding features â€" that is, computing and storage are independent of the service provider and can thus be fully scalable. For example, Hadoop ecosystem offerings are refined with Amazon’s or Google’s IaaS software.Integrated BDaaS. Integrated BDaaS has not yet been offered, but it would theoretically comprise out of both Performance and Feature BDaaS so as to allow maximum performance while supporting business owners.BDAAS FRAMEWORKBDaaS framework incorporates different layers according to the function each of them performs in the process of data storage, computing, and analysis. Data Infrastructure. The primary layer of BDaaS comprises out of data hardware and thousands of distributed computing unites (nodes) which are all interconnected and perform as a high-speed network lines through which the data fluctuates. This layer of BDaaS provides firewalls and backup system so as to prevent potential loss of data. As building your own database infrastructure can amount to expenditures of over 1.5 million dollars for 1000 square meters of space, BDaaS system’s infrastructure presents itself as the most profitable solution for the primary architectural sphere of data processing. Moreover, the profitability increases with the awareness that most businesses need data processing for specific information at sporadic intervals and would reach a negative ROI balance in case of building a new database each time.Cloud Infrastructure. Cloud infrastructure is the virtualized domain on which data, software and hardware interrelate. Cloud infrastructure can be private or pub lic and can be reserved in advance for a longer period (for example, several years), on demand (for a specific period of time during which particular processing will take place) or on spot (this option can have impact on availability of service as you cannot predict how much processors will be employed elsewhere). This layer does not include presentation access.Data Storage Layer. The data storage layer is highly accessible for customers as it enables direct upload of data for analysis. Moreover, the layer is horizontally scalable for requirements of data volume, velocity and variety and introduces new nodes according to the demand of these factors, as well as needs of particular industries and goals of the analysis.Computation Layer. Computation layer comprises out of technologies for performing distributed computing services such as processing frameworks and Application Programming Interfaces (APIs) whose objective is to manage and manipulate data according to requirements and cus tomer’s preferences (users can write programs themselves if there is sufficient expertise in programming and data analytics) with the objective of constructive information derivation from Big Data.Data Management. Data management layer undertakes procedures of maintenance and optimization of processing over the cloud platform. This includes system backups, deployments and resource requirements with the objective of safe-keeping of data and information as well as high efficiency.Data Analysis. The data analysis layer is the highest level of data processing in BDaaS and is in charge of analytical procedures regarding the underlying data. The customers access data through a web interface and create analytical reports and queries that are related to the data submitted to the storage layer. In order to maximize performance, this layer offers wizards and graphical tools which guide users through the process. Moreover, this layer of the BDaaS stack enables and offers customized approache s and applications with reference to specific industry-based requirements of users. Due to this feature of the data analysis layer, BDaaS proves to be highly productive system for diverse organizations and enterprises â€" because you can choose from technologies that will address important segments of your industry (for example, in finance industry, it will offer stock exchange graphs, risk monitoring and banking operation analytical and presentation tools.REQUIREMENTS FOR BDAASData governance. Effective data governance can make the difference between failure and success. With the overwhelming increase in both structured and unstructured data (90% of current raw data has been generated in the past two years) from points of sales, transaction records as well as from media, social networks and diverse information gathering techniques which are implemented in order to spur customer engagement through better understanding of their behavioral patterns, enterprises must govern their data conscientiously â€" targeting data which is to be analyzed with regard to their industry and business necessities â€" so as to extract actual value and profitability from the process.Data Security. While big organizations and companies have the means to purchase private cloud platforms for their enterprises that can be beneficial for security issues, small businesses cannot afford such endeavors. In order to ensure the safety of your data (and exclude risks of outside data manipulation) request a division of units of data and tasks undertaking across separate processors which cannot be connected without special permissions. Additionally, employ data backup systems that should prevent potential data loss.Data Strategy. The data that you intend to process should be structured with reference to layers of BDaaS through which it will be computing. If you design a structure of pathways through which the data will fluctuate, you will ensure a constructive process and eliminate potential i nconsistencies even before the process is put in motion.Dont focus solely on the volume, variety and complexity of data. Data analysis should serve a predefined set of objectives. Even predictive analysis procedures are a strategy of a sort (anticipation of possible trends and future tendencies). Hence, you should structure a strategy within which the results of data analysis will be incorporated. Determine short-term goals of the strategy in correlation with long-term goals of your enterprise. Additionally, monitor the process from data extraction to the final analysis in order to avoid the overly abstract set of information which cannot be implemented in the predefined strategies that you have created.Dont try to rush all data out to everyone all at once. As you incorporate analyzed data and information that derived from the process into your strategy, present it according to current requirements of your business. There is no need to flash out all of the information to everyone. U se the information timely and with a comprehensive awareness of its place within the current or future advances of your enterprise.ADVANTAGES DISADVANTAGES OF BDAASAdvantagesCloud Infrastructure: Enables instantiation of IT infrastructure and determines capabilities of overlying infrastructure (virtual machines and/or hardware);Data Storage: Access to raw data in distributed storage;Computing: Flexibility that arises from possible customized programming for data manipulation;Data Management: Direct access to data and possibilities for complex data analysis and modification;Data Analytics: Users can access analytics services without having to deal with data or programming spheres of BDaaS infrastructures;Scalability: Proper addressing of challenges regarding Big Data processing and not dependent on technology advances;Security: Responsibility for security issues is transmitted to the provider of the services;Service: Transferring time and finance consuming operations and technology development to a third party.DisadvantagesCloud Infrastructure: Infrastructure knowledge requirement â€" challenge regarding expertise;Data Storage: Programming knowledge requirement â€" challenge regarding expertise;Computing: Programming knowledge requirement â€" challenge regarding expertise;Data Management: Programming knowledge requirement â€"challenge regarding expertise;Data Analytics: No direct access to data and analytics services are restricted to the data which is in the data analytics layer;Security: Potential negative manipulation of data by external parties â€" can influence business growth;Expertise Issues: As can be seen in above-mentioned parameters, lack of the skilled workforce presents a challenge that will have to be addressed in the future management of BDaaS technology.DIFFERENCES OF BDAAS TO TRADITIONAL BIG DATABig Data as a Service emerged as an answer to challenges of big data processing in order to increase enterprise competitiveness, productivity and long evity through the insightful implementation of valuable information. In this section, we will discuss the ways in which BDaaS proves to be more efficient than traditional approaches to Big Data processing.Increased influx of voluminous data over the past few years occurred while the environment was not suitable for its adequate management and utilization. The traditional environment was capable of processing only structured data with less developed analytical tools and techniques. Moreover, it lacked computational power and storage capacities for large amounts of diverse data.Traditional Big Data systems could address structured data processing requirements on distributed architectures and reached certain scalability in storage and computing as well as employed advanced analytical procedures. However, the accessibility of these systems was still limited and derived from custom coding.Big Data as a Service enables processing structured and unstructured data (80% of data which is obta ined by companies is unstructured) with advanced analytical tools. Moreover, it offers cloud-based distributed computing services with possibilities of scaling up as well as ubiquitous availability and on-demand opportunities. BDaaS offers both specified domain-based algorithms and custom coding possibilities from which analytical capability derives. Further on, it stores data on virtualized cloud platforms.With the increased amounts of big data which is fluctuating in relation to market and its constituents with enterprises, entrepreneurs can employ accessible BDaaS technologies and services in order to endure and prevail among the competition. Business growth is nowadays dependent on obtaining valuable insights on the patterns of behavior, as well as changes in the market and reacting appropriately to these properties. By using BDaaS technology, these requirements can be met without driving your business into bankruptcy. It can be hard to discard all of the traditional approaches and methods which have been used in business for much longer than the new ones which are emerging at every corner but it does not change the fact that you must transfer into the progressive and active business management in order to survive on the market.

The Life and Work of Francois-Marie Arouet, a.k.a. Voultaire

Many classic books of literature of the French Enlightenment era comes from the famous author Francois-Marie Arouet, better known as his pen name, Voltaire.The French author was born on November 21st, 1694 and died May 30th, 1778 in the city of Paris. He started school at the Jesuit College of Louis-le-Grand at the age of 10 and graduated in 1711 with a motive of being a writer. However, Voltaire’s father did not agree with his choice of study and wanted Voltaire to study law. He went back to school to study law for another two years after his graduation. Voltaire was sent to The Hague, Netherlands in order to act as a secretary to the French ambassador at the time. During his visit, he became infatuated with Catherine Olympe de Noyer. Due†¦show more content†¦As the two were conversing, the man returns to Cunà ©gonde and is killed by Candide. Not knowing what to do, the trio flees onto a boat headed towards South America. Once they arrived at the city of Buenos Aire s, Candide and Cunà ©gonde had planned to marry but is interrupted after the governor proposes to Cunà ©gonde. She accepts without conferring to Candide about it. The authorities were on the lookout for Candide after the murder of the Jewish man back in Europe. He flees to an area surrounded by Jesuits, who are rebelling against the Spanish regime, and encounters Cacambo along his journey. He later discovered that the baron is surviving as the commander of the Jesuit group. Candide’s optimistic attitude is slowly depleting as the baron announces that Cunà ©gonde would never wed a person such as Candide. Enraged by the statement, Candide penetrates a sword through the baron and flees with Cacambo. After committing another murder in the Jesuit territory, Candide and Cacambo travel to the city of El Dorado. The utopian city was made out of various treasures and had perfect living conditions for anyones desire. However, Candide still dedicates his heart to Cunà ©gonde and dec ides to buy her back with the finite amount of gold and jewels. Once they depart the city of gold and into the country of Suriname, Candide sends Cacambo to buy back Cunà ©gondes freedom with their hoard of treasures and tells him to meet again in Venice. Candide decides to sail off to

The Utopian Society In 1984 By George Orwell - 1783 Words

The modern world still deals with racism and dehumanization, but nothing could compare to how people were treated way back in the olden days. To be living in a utopia, it is described to be â€Å"A place of ideal perfection especially in laws, government, and social conditions† (â€Å"Utopia†). Meanwhile, the opposite of that society is called a dystopia, which is â€Å"A society characterized by human misery, as squalor, oppression, disease, and overcrowding† (â€Å"dystopia†). It is believed that any utopian society does not remain one, for there is no possible way every person in a community thinks the same way about what a perfect society looks like. In the novel 1984 by George Orwell, there is a broad known fact that the Party creates an illusion of a†¦show more content†¦They are blind to the truth, and it is very easy to see that when we learn about the different people living in this community. Mr. Parson’s is a character that was i ntroduced to us while Winston was fixing the Parson’s sink. As Winston states, â€Å"He was a fattish but active man of paralyzing stupidity, a mass of imbecile enthusiasms—one of those completely unquestioning, devoted drudges on whom, more even than on the Thought Police, the stability of the Party depended† (Orwell 22). To the government of Oceania, Mr. Parson’s is quite literally the ideal person in their society. He is not too bright, and believes everything Big Brother does is for the best, and that he makes no mistakes. While drilling the fact that this is best life for all people in Oceania’s brains, they also have come up with the new language to ensure everything from the past will be forgotten about. The language is called Newspeak, and they have implicated it into their system so that sooner or later, regular English will be used ever so rarely. The new language contains very little verbs, so the community is not using as much vocabular y, and driving up their intelligence. Winston was with his friend Syme at the cafeteria when Syme brought up the fact of how they should be using this new vocabulary. Syme explains, â€Å"‘Has it ever occurred to you, Winston, that by the year 2050, at the veryShow MoreRelatedEssay on George Orwells 1984667 Words   |  3 PagesOrwells 1984 1984 as an Anti-Utopian Novel A utopia is an ideal or perfect community. While some writers have created fictional places that embody their ideals societies, other writers have written satires that ridicule existing conditions of society, or anti-utopias, which show possible future societies that are anything but ideal. 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Knowing About the Comparisons Between Ball Mill and Vertical Mill Free Essays

For a long time, ball mill has been a key equipment for high capacity grinding demand. Nowadays, vertical mill will be active in this field. You must want to know the comparison between them, please read as follows: 1). We will write a custom essay sample on Knowing About the Comparisons Between Ball Mill and Vertical Mill or any similar topic only for you Order Now Higher grinding efficiency. Vertical mill grind material in material bed, engergy cost will be 30% lower than ball mill, as sound engergy and thermal energy will cause energy loss in ball mill. 2). Simpler process flow and less investment need in infrastructure. Simpler design in powder transmission ensures less breakdown time and better operation; compact arrangement requires only 70% building area and 50%-60% building space of that for ball mill. 3). Excellent performance in drying. As material is transferred by hot steam, wind temprature can be controlled to dry material with moisture of 12%-15% ready for grinding, while that for ball mill can only be 3%-4%. 4). Less consumption of metal parts. As there is no direct contact between different metal parts, metal consumption and iron content of final product will be reduced a lot, which will be good for final product quality. 5). Less noise and dust. Noise can be reduced by 20-25 db comparing with ball mill and dust will be reduced greatly thanks to it’s subpressure design. 6). Powder is more even. As qualified products can be seperated in time and over grinding can be avoided, which can provide more even powder comparing with ball mill, in which over grinding is inevitable. Meanwhile, grain size can be adjusted easily by a unique system. ball mill: http://www. hxjq-crusher. com/20. html Stone crushing plant: http://www. hxjqchina. com/n26. html vibratory feeder: http://www. hxjqchina. com/product-list_14. html Stone production line: http://www. hxjq-crusher. com/64. html How to cite Knowing About the Comparisons Between Ball Mill and Vertical Mill, Papers

Knowing About the Comparisons Between Ball Mill and Vertical Mill Free Essays

For a long time, ball mill has been a key equipment for high capacity grinding demand. Nowadays, vertical mill will be active in this field. You must want to know the comparison between them, please read as follows: 1). We will write a custom essay sample on Knowing About the Comparisons Between Ball Mill and Vertical Mill or any similar topic only for you Order Now Higher grinding efficiency. Vertical mill grind material in material bed, engergy cost will be 30% lower than ball mill, as sound engergy and thermal energy will cause energy loss in ball mill. 2). Simpler process flow and less investment need in infrastructure. Simpler design in powder transmission ensures less breakdown time and better operation; compact arrangement requires only 70% building area and 50%-60% building space of that for ball mill. 3). Excellent performance in drying. As material is transferred by hot steam, wind temprature can be controlled to dry material with moisture of 12%-15% ready for grinding, while that for ball mill can only be 3%-4%. 4). Less consumption of metal parts. As there is no direct contact between different metal parts, metal consumption and iron content of final product will be reduced a lot, which will be good for final product quality. 5). Less noise and dust. Noise can be reduced by 20-25 db comparing with ball mill and dust will be reduced greatly thanks to it’s subpressure design. 6). Powder is more even. As qualified products can be seperated in time and over grinding can be avoided, which can provide more even powder comparing with ball mill, in which over grinding is inevitable. Meanwhile, grain size can be adjusted easily by a unique system. ball mill: http://www. hxjq-crusher. com/20. html Stone crushing plant: http://www. hxjqchina. com/n26. html vibratory feeder: http://www. hxjqchina. com/product-list_14. html Stone production line: http://www. hxjq-crusher. com/64. html How to cite Knowing About the Comparisons Between Ball Mill and Vertical Mill, Papers

Michael Jordan Essays (984 words) - Chicago Bulls,

Michael Jordan Michael Jordan was one of five children born to James and Delores Jordan. He was born February 17, 1963 in Brooklyn. His parents felt that the streets of Brooklyn were unsafe to raise a young family. So instead of trying to endure the streets of Brooklyn, the Jordan family moved to Wilmington, North Carolina. Michael's father, James, got a job in Wilmington as a mechanic and his mother Delores got a job as a teller at United Carolina Bank. Michael always had an eye for baseball. He played as an outfielder and as a pitcher. When he was twelve, he was the top player in his league. By the age of fifteen, he wasn't the star in baseball as he once was. He was still very good, but he had lost some of his focus. Later, in his high school career, he dropped baseball to pursue another interest. Soon Michael adopted the game of basketball. When Michael reached the ninth grade, he tried out for the basketball team. Coach Lynch, Michael's coach, cut Michael, which in turn may have made the best player alive today. Michael then took practicing basketball to another level. He played his brother Larry whenever he could. Michael never expected what would come in the near future. Michael Jordan went to the University of North Carolina as a basketball recruit. Even though Jordan at 6'5" was a man with potential, he still studied very hard in an attempt to get a good education, while competing in sports. Mike wasn't expected to be a star of the Tar Heels, since they had players such as James Worthy, Sam Perkins, and Al Wood. But, by the end of the 1981-82 season, Jordan, as a freshman, was an everyday starter. Carolina reached the Final Four with the help of Jordan, who had sixteen points and led the team with nine rebounds. In the final twenty seconds, Michael made a title winning shot from the left baseline. In Michael's sophomore and junior seasons, he was voted College Basketball's Player of the Year. Through Michael's three years at Carolina, he average 17.7 points per game, while maintaining a "B" average. After a great college career, the Chicago Bulls as the third pick of the 1984-85 season drafted Michael. Michael made a huge impact in the NBA (National Basketball Association). He made such an impact that he was selected to be an alternate on the Eastern Division all-star squad. With Michael's growing success in the NBA, more and more companies wanted to use the "Air Jordan" name. One of the first companies to use his name was Nike. Nike paid Michael $2.5 million, so they could begin a line of shoes known as "Air Jordan's ?During the 1987-88 season, Jordan raised his game to another level. The Bulls' status was also raised to another level with the additions of Scottie Pippen and Horace Grant. Michael was having another great season and this was evidenced when he started on the Eastern Division all-star squad.?(Website) He then finished the season, leading the Bulls in scoring for 81 games out of the 82 game season. For his efforts, Jordan was selected as the Most Valuable Player and as Defensive Player of the Year. Throughout the rest of the few years Chicago went on a rampage. They had received the best records in history, and with the help of Michael they went on to win three NBA championships. Michael Jordan announced after winning his third consecutive NBA championship that he was stepping down from the game he loved. He said that he was tired of the pressures. Some people believe that Jordan's gambling debts caused Jordan to quit. Others believe that the slaying of his father, which happened on August 15, 1993, caused Jordan to quit. There is one final theory that Michael wanted to pursue one of his childhood dreams, professional baseball. Michael Jordan announced that he would pursue his dream of playing baseball. Jordan joined the Chicago White Sox organization. The White Sox gave Jordan a tryout and then decided that he would be best playing with the Birmingham Barons. When Mike hit his first home run on July 30,he pointed to the sky honoring

Free Essays on Racial Discrimination During The 1920s

Racial and Ethnic Discrimination during the 1920's During the 1920’s, racial tensions in American society reached a boiling point. New non-protestant immigrants like Jews and Catholics had been arriving in huge masses from southeast Europe since the beginning of the century. Together, with Orientals, Mexicans, and the African-American population, these minorities suffered at the hands of those concerned with preserving the long established White Anglo-Saxon Protestant (W.A.S.P.) values that were an integral part of American life. Prejudice and racism reared its ugly head in many areas of society, with people showing a tolerance for racist views in the media, literature, and towards organizations like the Ku Klux Klan. Also, the language, living and working conditions, and Government legislations that ethnic minorities were subjected to is further evidence that the Twenties were an openly discriminatory decade. It was also during this period of grave hostility directed at ethnic groups that America’s ‘open door ’ attitude of â€Å"give me your tired, your poor†¦Ã¢â‚¬  officially became a part of its history. During the â€Å"Roaring Twenties†, anti-immigration organizations that had been founded in the 1900’s began to receive more support and became increasingly influential following the First World War. The Immigration Restriction League (I.R.L.) was one such group, which claimed to have scientific evidence that the new immigrants from southeast Europe were racially â€Å"inferior† and therefore posed a threat to the supremacy of the United States. They believed strongly in W.A.S.P. values and certainly did not wish to see them become polluted by other religions from minority groups. This Social-Darwinist belief was not just popular with the masses, but it’s appeal spread to people of considerable eminence. For example, the principals of important American universities like Harvard and Stanford were numbered among the I.... Free Essays on Racial Discrimination During The 1920's Free Essays on Racial Discrimination During The 1920's Racial and Ethnic Discrimination during the 1920's During the 1920’s, racial tensions in American society reached a boiling point. New non-protestant immigrants like Jews and Catholics had been arriving in huge masses from southeast Europe since the beginning of the century. Together, with Orientals, Mexicans, and the African-American population, these minorities suffered at the hands of those concerned with preserving the long established White Anglo-Saxon Protestant (W.A.S.P.) values that were an integral part of American life. Prejudice and racism reared its ugly head in many areas of society, with people showing a tolerance for racist views in the media, literature, and towards organizations like the Ku Klux Klan. Also, the language, living and working conditions, and Government legislations that ethnic minorities were subjected to is further evidence that the Twenties were an openly discriminatory decade. It was also during this period of grave hostility directed at ethnic groups that America’s ‘open door ’ attitude of â€Å"give me your tired, your poor†¦Ã¢â‚¬  officially became a part of its history. During the â€Å"Roaring Twenties†, anti-immigration organizations that had been founded in the 1900’s began to receive more support and became increasingly influential following the First World War. The Immigration Restriction League (I.R.L.) was one such group, which claimed to have scientific evidence that the new immigrants from southeast Europe were racially â€Å"inferior† and therefore posed a threat to the supremacy of the United States. They believed strongly in W.A.S.P. values and certainly did not wish to see them become polluted by other religions from minority groups. This Social-Darwinist belief was not just popular with the masses, but it’s appeal spread to people of considerable eminence. For example, the principals of important American universities like Harvard and Stanford were numbered among the I....

Free sample - Ethical Standards. translation missing

Ethical Standards. Ethical StandardsMoral and ethical aspects of human life are very important for the personal development and statement. These life values determine attitude towards people, God and family. They are not regulated by law or other governmental documents, and there is no determined punishment for their violation, but still breaking ethical rules means breaking own personality and acting against oneself. 1. Ethical standard in majority of cases is taken from the parents’ family, social life, religion and historical period. Also, some people think that social groups, mentality and corporate culture, make impact on ethical standards formation. In other words, it is possible to consider the social environment as a major factor, which influences the ethical and moral standards of the personality. 2. According to the respondents’ point of view, those standards of personal ethics, which were grounded by parents in the childhood, are completely impossible to change because personality makes all important life decisions and actions, according to these standards. In some cases, it is possible to make some impact for the personal ethics while changing environment and religious- person would have to adapt to the new life conditions and to the people, surrounding him or her with their life principles. 3. In most cases ethical standards consider God as the main judge of all our actions. The God is also represented for many people as the personal example on how people should live and act. Family values are the core principle of ethics and people think that it is impossible to be fair with him/herself without being fair in own family. Parents, kids and beloved are the sense of life. Belief in afterlife time – one more important issue in following all ethical norms and standards. Respondents consider the afterlife time as the remuneration for the fair and faithful life, for acting, according to the ethical norms. References: Auditing Practices Board (2010) Ethical Standards. [Online] (Updated 17 July 2010) World Health Organisation (2010) Ethical standards and procedures for research with human beings

Midwifery Code of Conduct Essay Example | Topics and Well Written Essays - 1500 words - 2

Midwifery Code of Conduct - Essay Example The healthcare industry is making efforts to offer and continue offering quality care and increase the credentials that enhance the competitiveness of organizations. Â  Scholars Lundy and Janes in their research argued that the main objective of healthcare administration is to ensure that the delivery of healthcare reaches residents in the efficient ways, to the required standards. Governments ensure that the provision of healthcare ensures continued support in the growth of the economies. This cannot be delivered if the administration and the organization as a whole do not prioritize work-life balance and team building among its employees as well as other stakeholders. Enhancing work-life balance is therefore very crucial to ensuring the success and stability of these organizations, and the companies should invest in promoting and building work-life balance for increased productivity and service delivery. This is a decisive move, applicable in building management and leadership to move in the leadership capacity of the health management and practitioners (Site, 2012). There are three potential models for healthcare organizations. These models a re corporate/business models, the orchestrator and the community model. These models represent the different ways in which hospitals conduct their operations. The corporate model is for hospitals, which are operated as financial entities. These hospitals’ main aim is making profit just like any other business. The orchestrator model is for hospitals, which are operated, similar to airports or malls. In this model, hospitals are looked at as providers of infrastructure for specialized and independent health providers. The final model is the community model where the needs of people come before the finance issues (Site, 2012). Â  

What is a revolution Essay Example | Topics and Well Written Essays - 500 words

What is a revolution - Essay Example From whatever direction you approach it, revolution implies a need to consider the historical events before, during, and after a revolution. What were the precipitating factors that brought about the people’s call for change? How did they proceed to bring about the change? Did the change in fact accomplish the goals in the changes it brought about? There are many good examples of revolution to be considered; the French Revolution, the events of which began in 1787, when the call for change rang out among the French; and ended in 1799, with a new Constitution. Another famous revolution is the American Revolution, which lead to America’s independence from England. A revolution, which has not yet been identified as a revolution, and is one that, while it has been extensively discussed by notable authors and journalists such as Bernard Lewis, in his 2005 commentary entitled Freedom and Justice in the Modern Middle East; is perhaps better known as the War on Terrorism; is the Muslim Islamic revolution that has been ongoing since the time of the Prophet Mohammad (Lewis 1-26). â€Å"†¦Muslims – particularly those in the Middle East – have suffered new experiences that have transformed their vision of themselves and the world and reshaped the language in which they discuss it (1).† The experience of Muslims includes the occupation of Egypt by Napoleon, in 1798 (2). The social norms and French law that Napoleon brought with him and attempted to apply to Egypt’s Muslims, were in stark contrast to the laws of Islam (2). â€Å"The Koran,† Lewis writes, â€Å"for example, makes it clear that there is a duty of obedience: ‘Obey God, obey the Prophet, obey those who hold authority over you (6).’† The Koran also gives instructions concerning under what conditions, in case those conditions are not already made clear by the three previously cited dictates; by saying,

Dissection of Microrna-30Ds Function Roles

Dissection of Microrna-30Ds Function Roles DISSECTION OF MICRORNA-30DS FUNCTION ROLES IN MAMMALIAN PANCREATIC-BETA CELLS By:  Yiping Mao   ABSTRACT MicroRNAs (miRNAs) are a group of small non-coding RNAs (about 21-22 nucleotides long) that fine tune target protein output through messenger RNA degradation or inhibition of its translation. Recent studies showing that miRNAs and their function components respond to cellular stress to maintain steady state physiology of the cells. Since there are thousands of microRNAs existing in all kind of cells, their functional characterization during the normal states or stress conditions is not fully addressed yet. In this thesis, important aspects of pancreatic ÃŽÂ ²-cell function under normal or stress condition such as apoptosis, proliferation, insulin production and release and their regulation by the miRNA were explored. Pancreatic ÃŽÂ ²-cell is a group of insulin producing cells and plays critical role in maintaining glucose hemostasis. By combining mouse and cell line genetic approaches, high-throughput deep sequencing, a list of cell assays and molecular techniques, we have shed light on the novel roles of miR-30d, one highly expressed miRNA when ÃŽÂ ²-cell responding to high glucose stimulus, in regulating ÃŽÂ ²-cell mass on the middle aged mice. We demonstrated that overexpress of miR-30d deteriorated glucose tolerance ability of the mice with or without high fat diet treatment by significantly reducing the ÃŽÂ ²-cell mass with less insulin production. Additionally, we demonstrated that the reduced ÃŽÂ ²-cell mass is because both apoptosis pathway and proliferation p athway have been effected by miR-30d by targeting variety of protein factors expression. BCL2 interacting protein 3 (BNIP3) and cyclin E2 (CCNE2) have been respectively confirmed as miR-30ds targets and the effect of their regulation by miR-30d in pancreatic ÃŽÂ ²-cell proliferation or apoptosis aspects have been addressed as well. Furthermore, we could show that silencing of miR-30d in MIN6 cell (ÃŽÂ ²-cell mimicking cell line) by CRISPR-CAS9 gene editing system promotes the insulin secretion, which is through potentiated expression of MAFA, an insulin transcription factor. These studies uncovered novel functional roles of the miR-30d pathway in mediating ÃŽÂ ²-cell function and fate. Further dissection of these pathways shall uncover several mechanisms by which the ÃŽÂ ²-cells undertake to maximize their efficiency during disease states such as T2D.   CHAPTER 1: INTRODUCTION AND BACKGROUND 1.1 The Brief History of Diabetes and Research Long before terming diabetes, which means to pass through by Greek Apollonius of Memphis in 250 BCE and the re-discovery of honey-like-urine (glycosuria) by Thomas Willis, who included the term mellitus, Diabetes has discovered its first saying around 1500 B.C. in an Egyptian manuscript. It was perceived as a disease related with too great emptying of the urine (polyuria). Later, important discoveries includes Matthew Dobsons first proof of elevated urine and blood glucose levels (hyperglycemia) in people with diabetes (Dobson, 1776). In 1889, Joseph von Mering and Oskar Minkowski were the first to give evidence that pancreas removal in dogs induced diabetes, proposing that pancreas functional related to glucose levels. Afterward, Edward Albert Sharpey-Schafer proposed that diabetes could be brought on by losing a pancreatic chemical, which he named as insulin in 1910 (Polonsky, 2012). Taken together, diabetes is currently well recognized as a gathering of heterogeneous disorders cha racterized by hyperglycemia because of loss of insulin or its effectiveness. Current worldwide trends demonstrate a surprising 382 million individuals have diabetes and this is predicted to ascend to 592 million by the year 2035 (IDF Diabetes Atlas, 2013). The cases of diabetes complications, including diabetic retinopathy, cardiovascular disease and renal failure are constantly rising and the death rate because of those are worsen every year. Claude Bernards identification of liver as the major glucose production organ led to the first concept of homeostasis which has been termed and expanded by Walter Bradford in the mid-nineteenth century, to describe the maintaining of steady-state physiology of the cells (Robin, 1979). This gave the notion that actually the disturbed glucose homeostasis is one of the important events of the diabetes progression. Given the evidences of insulin is involved in maintaining the glucose homeostasis, Frederick Banting and Charles Best integrated a series of scientific approaches, and were able to purify the insulin from the pancreas. Moreover, they successfully treated the patients who suffer from the diabetes, with their purified insulin (Banting Best, 1922; Banting et al., 1922). This landmark finding set the stage for treating the severe diabetes with insulin. However, it has been almost a century now since the first time insulin was discovered and purified, diabetes remains the incurabl e disease, requires life-time attention and treatment because of its complexity. Diabetes has been classified as a couple different types nowadays, the major two types are known as the Type I Diabetes (T1D) or Insulin Dependent Diabetes Mellitus (IDDM) and Type II Diabetes (T2D) or Non-Insulin Dependent Diabetes Mellitus (NIDDM). Surprisingly, these two major types has been notified as early as 100-200 B.C by Indian physicians (Kahn, 1994). However, the first scientific evidence was brought by Wilhelm Falta and Harold Himsworth after they set the standardized glucose/insulin tolerance test in human to distinguish the insulin sensitive from non-sensitive patients (Himsworth, 1936). Insulin dependent T1D is featured in insufficient insulin production due to autoimmune response to the pancreatic beta-cells and it mostly affects young kids. T2D is more described as a metabolic syndrome with emergence of insulin resistance and obesity etc, and it is more common among adults (Moller, 2001). There is a complex network of several insulin responding tissues contributes to the maintenance of glucose homeostasis, and of course any abnormality in this network induces the progression of T2D. Besides the metabolic relevant tissues, the gene-interactions also play critical roles in the development of T2D and obesity such kind of metabolic diseases (Doria et al., 2008). 1.2 The Islet Architecture, ÃŽÂ ²-cell Fate determination The islets of Langerhans are specialized endocrine part of pancreas and are the only part producing the secreting hormones. They basically comprise of various cell sorts named ÃŽÂ ±, ÃŽÂ ², ÃŽÂ ´, PP, and ÃŽÂ µ that secret the islet hormones glucagon, insulin, somatostatin, polypeptide Y, and ghrelin individually, and these hormones are required to maintain the glucose homeostasis at normal or stress state. Furthermore, the islets are known to have dynamic and plastic architecture that is proposed to be adjusted over the time of development (Steiner et al., 2010). During the progression of insulin resistance, pregnancy or T2D, the islets extend in size to make up for expanded insulin requirement (Weir and Bonner-Weir, 2004; Kim et al., 2009). But afterwards, there is a considerable loss of ÃŽÂ ²-cell mass because of environmental or genetic factors, inducing the serious hyperglycemia in cause of insulin deficiency. While islets count to just ~1-2% of the whole pancreas, the insulin producing ÃŽÂ ²-cells represent ~65-80% of the islet mass, constituting to roughly 2% of pancreatic weight. Furthermore, the rest other cell types are considered as non ÃŽÂ ²-cells of the islets (Weir and Bonner-Weir, 2013). During the development, these distinctive cell types are known to emerge from a single progenitor cell that producing Neurogenin3 or Ngn3, a transcription factor that decides endocrine cell destiny (Edlund, 2002). Afterwards, other transcription factors, for example, Pdx1, Pax4, Nkx2.2, Nkx6.1, MafA, and Foxo1 help the ÃŽÂ ²-cell fate determination (Ziv et al., 2013). While it had been learned as that ÃŽÂ ²-cells proliferate by self-duplication from old ÃŽÂ ²-cells instead of differentiation from stem cell (Dor et al., 2004), some other study suggested that multipotent cells inside the pancreas could differentiate into ÃŽÂ ²-cells as well (Xu et al., 2008). The latter study is a lso confirmed by researches showing how expressing the ÃŽÂ ²-cell specific transcription factors in non ÃŽÂ ²-cell could trigger a ÃŽÂ ²-cell lineage in mice (Collombat et al., 2009; Al-Hasani et al., 2013). Recent studies additionally showing that non-ÃŽÂ ² cells, for example, ÃŽÂ ±-and ÃŽÂ ´-cells could experience transdifferentiation into ÃŽÂ ²-like cells when the mice is suffering from significant ÃŽÂ ²-cell loss (Thorel et al., 2010; Chera et al., 2014). On the other hand, a few researches demonstrate that the ÃŽÂ ²-cells can likewise lose their fate or dedifferentiate into non-ÃŽÂ ² or progenitor cells when losing any of the previously mentioned ÃŽÂ ²-cell particular transcription factor (Ziv et al., 2013). Moreover, a current study demonstrated that human ÃŽÂ ²-cells are capable of converting into ÃŽÂ ±-cells with no genetic modification (Spijker et al., 2013). Taken together, all these researches have showed that the dynamic plasticity of islet cells. 1.3 Glucose Stimulate Insulin Secretion One unique and significant feature of ÃŽÂ ²-cells is to detect the blood glucose changes and secrete insulin into extracellular milieu in response to keeping the glucose levels within the range of 4-8mM (Weir and Bonner-Weir, 2013). This is primarily accomplished by the take-up of extracellular glucose by the glucose transporter 2 (Glut2; Bell et al., 1990) at the plasma membrane. Upon uptake, the intracellular glucose sensor, glucokinase (Gck), subjects glucose moieties to quick metabolism system by glycolysis (Matschinsky and Ellerman, 1968). This brings about the producing of three carbon products: pyruvate, which takes part in the tricarboxylic corrosive (TCA) cycle inside the mitochondrion to eventually create adenosine triphosphates (ATP) by means of the electron transport chain system. The ATP therefore leads to the increase of ATP/ADP proportion in the cytoplasm, activating the closure of the ATP sensitive potassium (KATP) channel. Vitally, mutation in the kir6.2 subunit o f this channel were demonstrated to induce neonatal diabetes in both mice and human because of loss of insulin secretion as a consequence of constitutively open KATP channel (Koster et al., 2000; Gloyn et al., 2004). It has long been realized that glucose stimulates the closure of these KATP channels thus leading the slow menbrane depolarization (Ashcroft et al., 1984). This promotes extracellular calcium influx by voltage dependent calcium channels and potentiates the releasing of insulin (Matschinsky et al., 1998). Insulin is secreted in an oscillatory manner because of the blood glucose level and triggers downstream insulin signaling cascade in insulin-responsive tissues for the taking up glucose. It has well been shown that islets can be entrained to small changes in glucose and thus the plasma insulin has high frequency of oscillation. However, this capacity of entrainment of the islets is disturbed in patients with T2D (Mao et al., 1999). It exhibits ÃŽÂ ²-cell malfunction because of loss of insulin secretion is a major issue during the clinical indication of T2D. 1.4 Compensatory Islet Expansion During Insulin Resistance During the state of insulin resistance or over-weight, elevated plasma insulin levels (named hyperinsulinemia) has been found in polygenic mouse models showing insulin resistance and human subjects because of increasing of insulin secretion (Yalow and Berson, 1960; Polonsky et al., 1988; Brà ¼ning et al., 1997). It has been suggested later that both in rodents and people, this improved insulin secretion is apparently because of an expansion in ÃŽÂ ²-cell mass by either ÃŽÂ ²-cell proliferation (Steil et al., 2001) or ÃŽÂ ²-cell hypertrophy (Weir and Bonner-Weir, 2004). On the other hand, ÃŽÂ ²-cell failure because of different genetic or environmental variables, is known to cause declined plasma insulin levels in diabetics (Maclean and Ogilvie, 1955). It has been showed that lessened levels of insulin are frequently associated with a noteworthy loss of ÃŽÂ ²-cell mass because of ÃŽÂ ²-cell apoptosis (Butler et al., 2003; Rhodes, 2005). Other than the diabetes perspective, it has been demonstrated that matured ÃŽÂ ²-cells have long life-span and low proliferative rates at steady state. This is because of a potential limitation of the entry of matured ÃŽÂ ²-cells into cell cycle (Teta et al., 2005; Kushner, 2013). Other than this perception, later study suggested that adult ÃŽÂ ²-cells do have the ability to proliferate (Stolovich-Rain et al., 2012). In light of these findings on ÃŽÂ ²-cell proliferation, a few research groups have revealed various proteins essential for assisting ÃŽÂ ²-cell proliferation on knockout or transgenic mouse. Known cell cycle controllers including Cyclins D1 and D2, Cyclin subordinate kinase 4 (Cdk4), Cdk inhibitors (CKIs) such as Cip/Kip and INK4, transcription factors Retinoblastoma (Rb) and p53, have been proved on genetic mouse models as regulators of ÃŽÂ ²-cell proliferation and survival (Heit et al., 2006). Although transient high glucose has been considered as the result of insufficient insulin secretion or insulin resistance, it has also been revealed to promote the compensate ÃŽÂ ²-cell mass expansion (Bonner-Weir et al., 1989). This hypothesis was further supported recently by another observation, that it is the glucose metabolism, instead the glucose itself that triggers compensatory ÃŽÂ ²-cell proliferation in vivo (Porat et al., 2011). Some other attentions have been centered on the effect of activation of insulin/IRS2 pathway on driving ÃŽÂ ²-cell proliferation. The components of the pathway including IRS2 (Withers et al., 1998) and AKT (Bernal-Mizrachi et al., 2001) were demonstrated to be fundamental for ÃŽÂ ²-cell survival. Moreover, study has shown that the impact of insulin in ÃŽÂ ²-cell proliferation is even stronger when with hyperglycemia (Paris et al., 2003). It is notable that when in the state of severe insulin resistance, the pancreatic islets adjust t hemselves to meet the expanding requirement for producing and secretion more insulin by increasing their ÃŽÂ ²-cell mass (Weir and Bonner-Weir, 2004). Other than the involvement of protein coding genes, a few non-coding RNAs (ncRNAs), mostly microRNAs and long ncRNAs (lncRNAs), have been shown in the diabetogenes list, adding on to the complex genetic architecture of human diabetes. 2.1 The Brief History of MicroRNAs The most recent decade has seen huge attention regarding a new and special class of little ncRNAs such as microRNAs (miRNAs) in regulating the structure and function of ÃŽÂ ²-cells. With the first observation of a miRNA, lin-4 in C. elegans, researchers showed how a gene product encodes two little RNAs, instead of a protein. Besides, they demonstrated that these small RNAs binds to the compensatory sites at the 3 end of untranslated region (UTR) of lin-14, a development related heterochronic gene. This interaction is appeared to negatively regulate the expression of lin-14 by blocking its translation (Lee et al., 1993; Wightman et al., 1993), proposing miRNAs as negative regulators of gene expression. Even since the discovery of microRNAs, a lot of related research results have updated the mechanism of gene regulation to a novel level. miRNAs now are known as a group of small ncRNAs of ~21-22 nucleotides long that can complementary or non-complementary base-pairing the mRNA of protein coding genes, thus to regulate their expression at post-transcriptional level (Bartel, 2004 and 2009). Actually after the identification of lin-4, another miRNA called let-7 was revealed like lin-4 in both biogenesis and function level. Soon after, there starts a prevail in discovering new microRNASs mostly by high throughput sequencing technologies in research area and surprisingly, about 30,000 miRNA over about 200 species have been identified, which includes about 2,500 mature human miRNAs. (Kozomara and Griffiths-Jones, 2014). Many computational methods have also been produced to predict the potential targets of miRNAs based on the stable miRNA-target mRNA binding model (Lewis et al., 2003; Krek et al., 2005). 2.2 MicroRNA Induced Gene Silencing The intercellular gene silencing mechanism, termed as RNA silencing (RNAi) or post-transcriptional gene silencing (PTGS) is currently well known to be led by a group of small RNAs, for example, short interfering RNA (siRNA), piwi interacting RNA (piRNA), or the miRNAs. Basically, their working mechanisms are similar and the difference exist mostly in their biogenesis inside the cells (Ender and Meister, 2010). Mature miRNA producing has been through several steps: transcribed from DNA by RNA polymerase II, primary miRNA (pri-miRNA) has much longer sequence. Once transcribed, the pri-miRNA is further processed to precursor miRNA (pre-miRNA) about 60 nucleotides long by enzyme Dorsa and DGCR8 protein complex (Lee et al., 2003). Once pre-miRNAs are produced inside the nucleus, it will be export out of the nucleus by protein Exportin 5 to the cytoplasm in a Ran-GTP dependent manner (Lund et al., 2004). Another important enzyme, which is also critical for mouse development, Dicer would re cognize the pre-miRNA and process it to about 22 nucleotides long mature miRNA duplex form (Bernstein et al.,2003). Only one of stands of the duplex will be transported to miRNA-induced silencing complex (RISC) by Dicer, and the other strand, termed miRNA* is usually degraded in the end (Schwarz et al., 2003; Ender Meister, 2010). There are several components on the RISC, and one key protein component is AGO family. There are four well characterized members of AGO family in human AGO1, AGO2, AGO3 and AGO4. And AGO2 is expressed more often than other forms (Su et al., 2009; Wang et al., 2012). All the AGO proteins have the ability to slice mRNA because of their PAZ and PIWI cleavage domains under the guidance of miRNA sequence. Each miRNA has an important seed region, typically from 2nd-7th nucleotides, that could fully or partially bind to the mRNA 3 UTR sequence. The base pairing condition between the miRNA and target mRNA determines the target recognition and binding of miRISC, but also the fate of the mRNA- to be cleaved or to be repressed in translation. In animal system, the miRNA does not fully complementary bind to the 3 UTR of the target mRNA, through blocking the translation machinery, miRNA silencing the gene expression, without interference of the target stability. However, recent studies on the miR NA mediated gene silencing in mammalian cells reveals that miRNA may act through two step modes: at first, repressing the translation, then deadenylation and destabilization of target mRNA [27qualifier]. The deadenylation has been suggested to induce mRNA degradation [48] and translation inhibition is probably the requisite of mRNA degradation in mammalian cells [49].

Personal Life and Dear Fellow Students Essay

Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are very important, and yet, necessary component of a happy and healthy life. It helps the undeterred growth of our mind and body at the same time adding smile and tenderness to our daily life. Hence, the value of relaxing and having fun is just as significant as the importance of a dedicated working day at office, or a committed day of learning at school. As the saying goes â€Å"All work and no play makes Jack a dull boy† one must not only work hard but also devote equal time to nature the mental and physical aspect of life. Therefore, in essence, to position ourselves as well-formed, energetic and happy individuals in our society we must develop a balance between our work and entertainment, education and play. After all, what is the use of having a huge amount of wealth or knowledge if one doesn’t have a cheerful personality to enjoy them? Is there anyone out there willing to buy a painting at the cost of his or her eyes†¦? No one, am I right†¦? I am sorry to have chosen a harsh analogy, but in fact, this is what we do when we become mere workaholics. We sacrifice too heavily on something in search of happiness which ultimately turns out to be the very reason for our unhappiness! Respected judges, teachers and my dear fellow students – a very good morning to you all. Be it us, the students, our parents or the global workforce, the contemporary life of all of us has become extremely busy. We have developed kind of an object driven and materialistic attitude towards life and living. To the extent that we care only the marks and money! We don’t, or little realize that ceaseless working or studying reduces our efficiency and make our life dull and depressing. Dear fellow students, physical, recreational and relaxation activities are.